CTX: Bone Resorption Marker
Lower values = less bone breakdown
3 Months EVENITY + 9 Months Prolia
12 Months EVENITY
0.50
0.40
0.30
0.20
0.10
0
Switch to Prolia
Baseline
3 mo
6 mo
12 mo
Key point:
Prolia suppresses bone breakdown more powerfully than EVENITY. The 3-month group got stronger anti-resorption protection for 9 months, compensating for less time on EVENITY.
Adapted from Leder et al., Lancet Diabetes Endocrinol 2026