P1NP: Bone Formation Marker
Higher values = more new bone being built
3 Months EVENITY + 9 Months Prolia
12 Months EVENITY
100
80
60
40
20
0
Switch to Prolia
Baseline
3 mo
6 mo
12 mo
Key point:
Both groups show the same bone formation boost at 3 months. EVENITY's anabolic effect peaks early, then fades — which is why a shorter course can still be effective.
Adapted from Leder et al., Lancet Diabetes Endocrinol 2026